Monthly handle for September was $450.2m (£403.2m/€461.7m), up from $408.3m in the same month last year and also 55.2% ahead of $290.1m in August this year.
Consumers bet a total of $445.6m online during the month, in addition to $4.6m at retail sportsbook facilities across the state.
Gross gaming revenue reached $51.3m, which was 126.0% up from $22.7m in September 2021, while this total was 98.1% higher than $25.9m in August of this year.
Online wagering revenue was $50.7m, with just $659,647 being attributed to retail wagering activity during the month.
Football was by far the most popular sport to wager on in September, primarily due to the new NFL season beginning at the start of the month, with Colorado players spending a total of $145.7m.
Baseball wagers amounted to $83.2m and college football bets $52.7m, while parlay and combination wagers reached $75.3m.
Colorado collected $3.0m in sports betting taxes during the month, while win percentage for licensed operators in Colorado stood at 11.40%.